A7861

Asenapine maleate

≥98% (HPLC)

• Sinônimo(s): (3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12btetrahydro-1Hdibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate, Org 5222, trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate
• Fórmula empírica (Notação de Hill): C₁₇H₁₆ClNO ·C₄H₄O₄
• Número CAS: 85650-56-2
• Peso molecular: 401.84
• Número CE: 288-064-8
• Número MDL: MFCD00900588
• Código UNSPSC: 12352200
• ID de substância PubChem: 329770943
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to off-white
• solubilidade: H₂O: ≥10 mg/mL
• originador: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OC(=O)\C=C/C(O)=O.CN1C[C@H]2[C@H](C1)c3cc(Cl)ccc3Oc4ccccc24
• InChI: 1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1
• chave InChI: GMDCDXMAFMEDAG-CHHFXETESA-N

Descrição

Descrição geral

Asenapine maleate acts as an antimanic. It belongs to the family of dibenzoxepinopyrrolidines. Asenapine is considered to be a weak inhibitor of cytochrome P450 2D6 (CYP2D6). It increases the level of dopamine, norepinephrine and acetylcholine in brain.

Aplicação

Asenapine maleate has been used as a stressor in studying the Fos expression in forebrain structures of rat models.

Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania.

Ações bioquímicas/fisiológicas

Asenapine maleate is a 5-HT receptor antagonist (5-HT_1A,_1B, 5-HT_{2A, 2B, 2C}, 5-HT_5A, 5-HT₆ and 5-HT₇), a D2 antagonist, and an antipsychotic.

Características e benefícios

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H301,H315,H319,H335,H400
• Declarações de precaução: P273 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable