A5512

Aristolochic acid I

≥90% (HPLC), powder, phospholipase A₂ inhibitor

• Sinônimo(s): TR 1736
• Fórmula empírica (Notação de Hill): C₁₇H₁₁NO₇
• Número CAS: 313-67-7
• Peso molecular: 341.27
• Número CE: 206-238-3
• Número MDL: MFCD00004996
• Código UNSPSC: 41106300
• ID de substância PubChem: 24890982
• NACRES: NA.77

Propriedades

• Nome do produto: Aristolochic acid I, powder
• Ensaio: ≥90% (HPLC)
• Formulário: powder
• cor: yellow
• pf: 269-270 °C
• solubilidade: DMSO: soluble; ethanol: soluble
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C(O)=O
• InChI: 1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)
• chave InChI: BBFQZRXNYIEMAW-UHFFFAOYSA-N

Descrição

Descrição geral

Aristolochic acid is a naturally occurring plant metabolite found in Aristolochia sp, Bragantia sp. or Asarum sp. plants. It comprises a mixture of nitrophenanthrene carboxylic acids such as aristolochic acid I and II.

Aplicação

Aristolochic acid I have been used:

• as a standard for the analysis of Aristolochia sprucei crude extract by high-performance liquid chromatography
• to study its effects on histone deacetylase 3 (HDAC3) aberration and renal fibrosis
• to induce acute aristolochic acid nephropathy and to study its impact on miRNA and mRNA expression in mice

Ações bioquímicas/fisiológicas

Aristolochic acid is a potent inhibitor of phospholipase A2 (PLA2), hyaluronidase, and acetylcholinesterase plasma proteases from snake venoms. Aristolochic acid is considered a herbal medicine and shows therapeutic effects against obstetrics, snake bites, gout, and rheumatism. It exhibits anti-inflammatory and anti-malarial properties. In addition, it is also considered a genotoxic mutagen and causes aristolochic acid nephropathy (AAN), characterized by interstitial fibrosis and urothelial cancer.

Potent phospholipase A₂ inhibitor, including calcium ionophore-induced phospholipase A₂ activity in neutrophils. Kidney tumor initiator in experimental animal model.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H340,H350
• Declarações de precaução: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral - Carc. 1A - Muta. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges