A4352
Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Sinônimo(s):
Anti-phospho-AMPA Glutamate Receptor 1 (pSer831)
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About This Item
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
antigen 100 kDa
reatividade de espécies
rat, human
concentração
~1 mg/mL
técnica(s)
direct ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1:1,000 using rat brain (hippocampal) homogenate
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
phosphorylation (pSer831)
Informações sobre genes
human ... GRIA1(2890)
rat ... Gria1(50592)
Descrição geral
AMPA is a transmembrane receptor for glutamate that regulates synapsis in the central nervous system. It is composed of 4 types of subunits, GluR1, 2, 3, 4.
GluR1 subunits of AMPA receptors are membrane proteins that regulate synaptic plasticity of the central nervous system. This receptor has also been implicated in spatial memory retention. Phosphorylation of serine 831 in GluR1 subunit of the AMPA receptor modulates long-term potentiation in neuronal synapses. Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody is specific for the GluR1 subunit (phosphorylated on serine 831) of the AMPA receptor in rats and humans.
Imunogênio
The GluR1 sequence is conserved among species and has partial homology to VGLUT2.
synthetic phosphopeptide corresponding to a region near serine 831 of rat glutamate receptor subunit GluR1.
Aplicação
Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody is suitable for use in direct ELISA, immunohistochemistry, immunoblot and immunoprecipitation. The antibody may also be used for western blot (1:1,000 using rat hippocampal homogenate).
forma física
Solution in 10 mM HEPES buffer, pH 7.5, containing 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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recomendado
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Hey-Kyoung Lee et al.
Cell, 112(5), 631-643 (2003-03-12)
Plasticity of the nervous system is dependent on mechanisms that regulate the strength of synaptic transmission. Excitatory synapses in the brain undergo long-term potentiation (LTP) and long-term depression (LTD), cellular models of learning and memory. Protein phosphorylation is required for
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Journal of neurophysiology, 103(1), 479-489 (2009-11-13)
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