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92131

Sigma-Aldrich

Trimetropima

≥99.0% (HPLC)

Sinônimo(s):

2,4-Diamino-5-(3,4,5-trimetoxibenzil)pirimidina, NSC 106568

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About This Item

Fórmula empírica (Notação de Hill):
C14H18N4O3
Número CAS:
738-70-5
Peso molecular:
290.32
Beilstein:
625127
Número CE:
212-006-2
Número MDL:
MFCD00036761
Código UNSPSC:
51285203
ID de substância PubChem:
57653467
NACRES:
NA.85

fonte biológica

synthetic

Nível de qualidade

200

Ensaio

≥99.0% (HPLC)

forma

powder

cor

white to light yellow

pf

≥199.0 °C

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modo de ação

DNA synthesis | interferes
enzyme | inhibits

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

chave InChI

IEDVJHCEMCRBQM-UHFFFAOYSA-N

Informações sobre genes

human ... DHFRP1(573971) , KCNH1(3756)
rat ... Dhfr(24312)

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

Chemical structure: pyrimidine

Aplicação

Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae .
Usada principalmente como agente antibacteriano. Inibidora da di-hidrofolato redutase com seletividade para a enzima de procariotos.

Ações bioquímicas/fisiológicas

Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Embalagem

1g,5g,25g

Outras notas

Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H361d

Classificações de perigo

Acute Tox. 4 Oral - Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sulfamethoxazole VETRANAL®, analytical standard

Supelco

31737

Sulfamethoxazole

Sulfamethoxazole European Pharmacopoeia (EP) Reference Standard

S2100000

Sulfamethoxazole

Sulfamethoxazole certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

76177

Sulfamethoxazole

Sulfamethoxazole Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1126

Sulfamethoxazole

Cotrimoxazole, Ready Made Solution 100 mg/mL in DMSO

Sigma-Aldrich

A2487

Cotrimoxazole, Ready Made Solution

Sulfamethazine 99.0-101.0% (on dried basis)

Sigma-Aldrich

S6256

Sulfamethazine

Phosphomycin disodium salt antibacterial MurA inhibitor

Sigma-Aldrich

P5396

Phosphomycin disodium salt

R de Groot et al.
Antimicrobial agents and chemotherapy, 32(4), 477-484 (1988-04-01)
We studied 10 trimethoprim-resistant (Tmpr) Haemophilus influenzae isolates for which agar dilution MICs were 10 to greater than 200 micrograms/ml. Trimethoprim resistance was transferred from two Tmpr H. influenzae isolates to a Tmps strain by conjugation or transformation. Wild-type Tmpr
Susceptibility of Mycobacterium tuberculosis to sulfamethoxazole, trimethoprim and their combination over a 12 year period in Taiwan.
Tsi-Shu Huang1,2,3, Calvin M. Kunin, et al.
The Journal of Antimicrobial Chemotherapy, 10, 633-637 (2011)
Kate S Baker et al.
The Lancet. Infectious diseases, 15(8), 913-921 (2015-05-06)
Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who
Kyuho Han et al.
Nature methods, 11(1), 86-93 (2013-11-12)
Protein concentrations are often regulated by dynamic changes in translation rates. Nevertheless, it has been challenging to directly monitor changes in translation in living cells. We have developed a reporter system to measure real-time changes of translation rates in human
Sohei Harada et al.
Antimicrobial agents and chemotherapy, 54(9), 3545-3550 (2010-06-23)
Integrating conjugative elements (ICEs) are mobile genetic elements that can transfer from the chromosome of a host to the chromosome of a new host through the process of excision, conjugation, and integration. Although SXT/R391-related ICEs, originally demonstrated in Vibrio cholerae
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