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T0667

Sigma-Aldrich

Trimethoprim lactate salt

≥98%

Sinônimo(s):

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt

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About This Item

Fórmula empírica (Notação de Hill):
C14H18N4O3 · C3H6O3
Número CAS:
23256-42-0
Peso molecular:
380.40
Número CE:
245-533-1
Número MDL:
MFCD00171722
Código UNSPSC:
51285203
ID de substância PubChem:
329826610
NACRES:
NA.85

Nível de qualidade

200

Ensaio

≥98%

forma

powder

condição de armazenamento

(Keep container tightly closed in a dry and well-ventilated place.)

cor

white

solubilidade

H2O: soluble 20 mg/mL

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modo de ação

DNA synthesis | interferes
enzyme | inhibits

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)

chave InChI

IIZVTUWSIKTFKO-UHFFFAOYSA-N

Categorias relacionadas

Descrição geral

Chemical structure: pyrimidine

Aplicação

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

Ações bioquímicas/fisiológicas

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Frases de perigo

H301,H361d

Classificações de perigo

Acute Tox. 3 Oral - Repr. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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