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S2100000

Sulfamethoxazole

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, N1-(5-Methylisoxazol-3-yl)sulfanilamide

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About This Item

Fórmula empírica (Notação de Hill):
C10H11N3O3S
Número CAS:
723-46-6
Peso molecular:
253.28
Beilstein:
6732984
Número MDL:
MFCD00010546
Código UNSPSC:
41116107
ID de substância PubChem:
329824505
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

sulfamethoxazole

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1

InChI

1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)

chave InChI

JLKIGFTWXXRPMT-UHFFFAOYSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Sulfamethoxazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

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Sulfamethoxazole impurity A, European Pharmacopoeia (EP) Reference Standard

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Sulfamethoxazole impurity F, European Pharmacopoeia (EP) Reference Standard

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Sulfamethoxazole Related Compound C, United States Pharmacopeia (USP) Reference Standard

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Sulfamethoxazole Related Compound A, United States Pharmacopeia (USP) Reference Standard

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Sulfamethoxazole Related Compound F, United States Pharmacopeia (USP) Reference Standard

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Sulfamethoxazole Related Compound B, United States Pharmacopeia (USP) Reference Standard

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Sulfamethoxazole Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2578

Sulfamethoxazole Impurity A

Pictogramas

Health hazardEnvironment
GHS08,GHS09

Palavra indicadora

Warning

Frases de perigo

H361fd,H411

Classificações de perigo

Aquatic Chronic 2 - Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

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Certificados de análise (COA)

Lot/Batch Number

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Raquel González et al.
PLoS medicine, 11(9), e1001735-e1001735 (2014-09-24)
Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women taking daily cotrimoxazole prophylaxis (CTXp) because of potential added risk of adverse effects associated with
R E Levitz et al.
Annals of internal medicine, 100(6), 881-890 (1984-06-01)
Trimethoprim-sulfamethoxazole has excellent microbiologic activity against most pathogens that produce meningitis; both components of this drug have high penetration into tissues, including the cerebrospinal fluid. Clinical experience shows that trimethoprim-sulfamethoxazole may be beneficial in the treatment of gram-negative bacillary meningitis
Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy.
G P Wormser et al.
Drugs, 24(6), 459-518 (1982-12-01)
Jih-Tay Hsu et al.
Journal of hazardous materials, 277, 34-43 (2014-03-19)
Antibiotics are commonly used in swine feed to treat and prevent disease, as well as to promote growth. Antibiotics released into the environment via wastewater could accelerate the emergence of antibiotic-resistant bacteria and resistance genes in the surrounding environment. In
D H Lawson et al.
Reviews of infectious diseases, 4(2), 429-433 (1982-03-01)
A comprehensive review is presented of the world literature on adverse reactions to trimethoprim-sulfamethoxazole (TMP-SMZ) since its first use in 1968, when concern was expressed about possible hematologic toxicity. Serious toxicity is a rare event, but when it occurs severe
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