P5396

Phosphomycin disodium salt

antibacterial MurA inhibitor

• Sinônimo(s): (−)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphonomycin
• Fórmula empírica (Notação de Hill): C₃H₅Na₂O₄P
• Peso molecular: 182.02
• Beilstein: 4604425
• Número CE: 247-409-2
• Número MDL: MFCD22741288
• Código UNSPSC: 51102829
• ID de substância PubChem: 24278640
• NACRES: NA.85

Propriedades

• Nível de qualidade: 200
• forma: powder
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria
• Modo de ação: cell wall synthesis | interferes
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [Na+].[Na+].C[C@@H]1O[C@@H]1P([O-])([O-])=O
• InChI: 1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1
• chave InChI: QZIQJIKUVJMTDG-JSTPYPERSA-L

Descrição

Aplicação

Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine.

Ações bioquímicas/fisiológicas

Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.

Outras notas

1g,5g,50g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)