434R-1
ERG (EP111) Rabbit Monoclonal Primary Antibody
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
100
500
conjugado
unconjugated
forma do anticorpo
culture supernatant
tipo de produto de anticorpo
primary antibodies
clone
EP111, monoclonal
descrição
(For In Vitro Diagnostic Use in Select Regions (See Chart))
Formulário
buffered aqueous solution
reatividade de espécies
human
embalagem
vial of 0.1 mL concentrate (434R-14)
vial of 0.5 mL concentrate (434R-15)
bottle of 1.0 mL predilute (434R-17)
vial of 1.0 mL concentrate (434R-16)
bottle of 7.0 mL predilute (434R-18)
fabricante/nome comercial
Cell Marque™
técnica(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
Isotipo
IgG
controle
tonsil
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
visualização
nuclear
Informações sobre genes
human ... ERG(2078)
Descrição geral
ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.1 ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.1 ERG has also been observed to be positive in a minority of Ewing sarcomas.2 This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).5 ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.1
Qualidade
 IVD |  IVD |  IVD |  RUO |
Ligação
ERG Positive Control Slides, Product No. 434S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
forma física
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Nota de preparo
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Outras notas
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Informações legais
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Oksana Yaskiv et al.
American journal of clinical pathology, 138(6), 803-810 (2012-11-20)
Avian v-ets erythroblastosis virus E26 oncogene homolog (ERG) is highly sensitive and specific for endothelial neoplasms and specific for prostate carcinoma. We characterized a rabbit anti-ERG antibody as an immunohistochemical agent to detect ERG expression in various tumors using tissue
J R Bänffer et al.
Antonie van Leeuwenhoek, 53(3), 183-190 (1987-01-01)
The immune response was studied in 238 human patients with Campylobacter jejuni/coli (CJC)-infections in Rotterdam by the counterimmunoelectrophoresis (CIE) test, a commercial complement fixation test (CFT) and the passive haemagglutination test (HA). Antibodies became detectable in the three tests around
Jason L Hornick
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27 Suppl 1, S47-S63 (2014-01-05)
Immunohistochemistry plays a key role in the diagnosis of soft tissue tumors. Until recently, however, the primary purpose of immunohistochemistry in this context was simply to attempt to demonstrate a line of differentiation. Unfortunately, most traditional markers (predominantly directed against
Sarah Minner et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(1), 106-116 (2012-08-18)
Approximately 50% of prostate cancers are characterized by TMPRSS2 (transmembrane protease serine 2)-ERG (avian v-ets erythroblastosis virus E26 oncogene homolog) gene fusions resulting in an androgen-regulated overexpression of the transcription factor ERG. Some studies have suggested prognostic or predictive relevance
Markku Miettinen et al.
The American journal of surgical pathology, 35(3), 432-441 (2011-02-15)
ERG, an ETS family transcription factor, is known to be expressed in endothelial cells, and oncogenic ERG gene fusions occur in subsets of prostatic carcinoma, acute myeloid leukemia, and Ewing sarcoma. In this study, we immunohistochemically investigated nuclear ERG expression
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