394R-1

Stathmin (SP49) Rabbit Monoclonal Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100; 500
• conjugado: unconjugated
• forma do anticorpo: culture supernatant
• tipo de produto de anticorpo: primary antibodies
• clone: SP49, monoclonal
• descrição: For In Vitro Diagnostic Use in Select Regions (See Chart)
• forma: buffered aqueous solution
• reatividade de espécies: human
• embalagem: vial of 0.1 mL concentrate (394R-14); vial of 0.5 mL concentrate (394R-15); bottle of 1.0 mL predilute (394R-17); vial of 1.0 mL concentrate (394R-16); bottle of 7.0 mL predilute (394R-18)
• fabricante/nome comercial: Cell Marque^™
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• Isotipo: IgG
• controle: cervical intraepithelial neoplasia – high grade, tonsil
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• visualização: cytoplasmic
• Informações sobre genes: human ... STMN1(3925)

Descrição

Descrição geral

The distinction between high grade cervical intraepithelial neoplasia (CIN2/3) from low grade cervical intraepithelial neoplasia (CIN1) is clinically significant with treatment recommendations linked specificallyto risk of cancer or CIN3 outcome. CIN1 will progress into invasive carcinoma in <1% of cases and is typically managed with Papanicolaou smear follow-up, whereas CIN2/3 has a 5% to 20% risk of progression1 and is usually treated with an excisional procedure (loop electrosurgical excision procedure or cone biopsy).1 Stathmin, also referred to as Stathmin-1 and oncoprotein18, is a ubiquitous microtubule-destabilizing protein shown to be important during mitosis and has been implicated as a regulator of cell motility and migration.

Recent studies show anti-stathmin is positive in 24/82 (29%) CINs with differential expression based on the grade of the lesion as 5/56 (9%) CIN1, 5/11 (45%) CIN2, and 14/15 (93%) CIN3; whereas, anti-p16 staining of the same cases was immuno-reactive in 66/83 (80%) CINs, including 40/56 (71%) CIN1, 11/11 (100%) CIN2, and 15/16 (94%) CIN3. Anti-stathmin shows similar sensitivity for CIN3 to anti-p16 (93% vs 94%) although it drops off for CIN2 (73% vs 96%). The specificity of anti-stathmin for both CIN2/3 (94%) and CIN3 (89%) is higher than that of anti-p16 (44% and 39%, respectively). Anti-Stathmin stains basal layer of normal benign ectocervix. A well-oriented fragment of cervix tissue would increase the accuracy of diagnosis. In conclusion, based on recent studies, anti-stathmin has a higher specificity relative to anti-p16; therefore, anti-stathmin has major potential as a diagnostic marker in CIN classification over anti-p16.

Qualidade

IVD

IVD

IVD

RUO

Ligação

Stathmin Positive Control Slides, Product No. 394S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable