496219

N,N-Diisopropylethylamine

99.5%, biotech. grade

• Sinônimo(s): N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine, ‘Hünig’s base’
• Fórmula linear: [(CH₃)₂CH]₂NC₂H₅
• Número CAS: 7087-68-5
• Peso molecular: 129.24
• Número CE: 230-392-0
• Número MDL: MFCD00008868
• Código UNSPSC: 12352116
• ID de substância PubChem: 329757490
• NACRES: NA.21

Propriedades

• grau: biotech. grade
• pressão de vapor: 31 mmHg ( 37.7 °C)
• Ensaio: 99.5%
• Formulário: liquid
• Impurezas: <0.050% water
• cor: APHA: <20
• índice de refração: n20/D 1.414 (lit.)
• pH: 12.3 (20 °C)
• p.e.: 127 °C (lit.)
• pf: <−50 °C (lit.)
• solubilidade: water: soluble 4.01 g/L at 20 °C
• densidade: 0.742 g/mL at 25 °C (lit.)
• aplicação(ões): peptide synthesis
• cadeia de caracteres SMILES: CCN(C(C)C)C(C)C
• InChI: 1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
• chave InChI: JGFZNNIVVJXRND-UHFFFAOYSA-N

Descrição

Descrição geral

N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.

N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.

Aplicação

N, N-Diisopropylethylamine can be used as a base:

• In the palladium (0)-catalyzed alkoxy carbonylation of allyl phosphates and acetate.
• In the selective enolate formation along with boryl triflates.
• In the C–N coupling of aryl halides with nitroarenes in the presence of nickel catalyst.

N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.

Informações de segurança

• Pictogramas: GHS02,GHS06,GHS05,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H225,H302,H318,H331,H335,H411
• Declarações de precaução: P210 - P273 - P280 - P301 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 49.1 °F
• Ponto de fulgor (°C): 9.5 °C