Y0001761

Nicorandil

European Pharmacopoeia (EP) Reference Standard

• Sinônimo(s): 2-(Pyridine-3-carbonylamino)ethyl nitrate, 2-Nicotinamidoethyl nitrate, Ikorel, N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide, SG-75, Sigmart, Zynicor
• Fórmula empírica (Notação de Hill): C₈H₉N₃O₄
• Número CAS: 65141-46-0
• Peso molecular: 211.17
• Número MDL: MFCD00186520
• Código UNSPSC: 41116107
• ID de substância PubChem: 329831558
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: nicorandil
• fabricante/nome comercial: EDQM
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [O-][N+](=O)OCCNC(=O)c1cccnc1
• InChI: 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
• chave InChI: LBHIOVVIQHSOQN-UHFFFAOYSA-N

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Nicorandil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS02,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H242,H302
• Declarações de precaução: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Classificações de perigo: Acute Tox. 4 Oral - Org. Perox. D
• Código de classe de armazenamento: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable