BP1103

Nicorandil

British Pharmacopoeia (BP) Reference Standard

• Sinônimo(s): 2-(Pyridine-3-carbonylamino)ethyl nitrate, 2-Nicotinamidoethyl nitrate, Ikorel, N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide, SG-75, Sigmart, Zynicor
• Fórmula empírica (Notação de Hill): C₈H₉N₃O₄
• Número CAS: 65141-46-0
• Peso molecular: 211.17
• Número MDL: MFCD00186520
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: nicorandil
• Formulário: solid
• prazo de validade: limited shelf life, expiry date on the label
• fabricante/nome comercial: BP
• aplicação(ões): pharmaceutical; pharmaceutical small molecule
• Formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [O-][N+](=O)OCCNC(=O)c1cccnc1
• InChI: 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
• chave InChI: LBHIOVVIQHSOQN-UHFFFAOYSA-N

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Nicorandil BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Nicorandil Tablets

Ações bioquímicas/fisiológicas

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor.

Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Embalagem

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS02,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H242,H302
• Declarações de precaução: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Classificações de perigo: Acute Tox. 4 Oral - Org. Perox. D
• Código de classe de armazenamento: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable