T3383

Tetracycline hydrochloride

≥95% (European Pharmacopoeia HPLC assay)

• Sinônimo(s): 4-Epitetracycline hydrochloride, Achromycin hydrochloride
• Fórmula empírica (Notação de Hill): C₂₂H₂₄N₂O₈ · HCl
• Número CAS: 64-75-5
• Peso molecular: 480.90
• Beilstein: 3844873
• Número CE: 200-593-8
• Número MDL: MFCD00078142
• Código UNSPSC: 51284043
• ID de substância PubChem: 24900135
• NACRES: NA.76

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥95% (European Pharmacopoeia HPLC assay)
• Formulário: powder
• condição de armazenamento: (Keep container tightly closed in a dry and well-ventilated place.)
• cor: yellow
• pf: 220-223 °C (lit.)
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria
• Modo de ação: protein synthesis | interferes
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
• chave InChI: XMEVHPAGJVLHIG-FMZCEJRJSA-N

Descrição

Descrição geral

Chemical structure: tetracycline

Aplicação

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.

Ações bioquímicas/fisiológicas

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Atenção

This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.

Nota de preparo

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Informações de segurança

• Pictogramas: GHS08,GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335,H361fd,H410
• Declarações de precaução: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves