SBR00025

Novobiocin Ready Made Solution

100 mg/mL in water

• Sinônimo(s): Novobiocin Ready Made Solution
• Fórmula linear: C₃₁H₃₅N₂NaO₁₁
• Peso molecular: 634.61
• Código UNSPSC: 51286504
• NACRES: NA.76

Propriedades

• fonte biológica: microbial
• Nível de qualidade: 100
• Ensaio: ≥90%
• Formulário: liquid
• concentração: 100 mg/mL in water
• cor: faint yellow to dark brown
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; neoplastics
• Modo de ação: DNA synthesis | interferes; enzyme | inhibits
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic commonly derived from Streptomyces Sp. It exerts its antibacterial activity by inhibiting Topo II α, which corresponds to bacterial DNA gyrase. It is effective against both gram-positive and gram-negative bacteria and is significant in research involving highly beta-lactam-resistant pneumococcal infections and anti-orthopoxvirus applications. Functioning as a competitive inhibitor in the ATPase reaction catalyzed by GyrB, Novobiocin is employed in microbiology and cell biology research to effectively prevent the growth of bacterial contaminants.

Aplicação

Novobiocin has been used:

• in cell culture systems to treat mycoplasma contaminations.[3]
• in a research to where it has exhibited anti-cancer effects by inhibition of Hsp90 (heat shock protein)[4],[5]

Ações bioquímicas/fisiológicas

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II

Activity spectrum: Active against gram-positive and gram-negative bacteria

Características e benefícios

• Ready available solution reduce the need for preparation time
• Commonly used in Cell Biology and Biochemical applications
• High quality antibiotic suitable for mulitple research applications

Nota de preparo

Novobiocin Ready Made Solution is light sensitive. Thaw this product at room temperature. It is recommended to avoid repeated freeze thaw cycles of this product. The suggested concentration of Novobiocin for cell culture assays is 50-1000 μg/mL,^,, therefore, it is recommended to dilute the Ready Made Solution 1:100-2000.

Outras notas

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Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H317
• Declarações de precaução: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classificações de perigo: Skin Sens. 1
• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable