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Key Documents

PHR1855

Supelco

Telmisartan

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Telmisartan, 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid, BIBR 277

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About This Item

Fórmula empírica (Notação de Hill):
C33H30N4O2
Número CAS:
Peso molecular:
514.62
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to Ph. Eur. Y0000648
traceable to USP 1643419

família API

telmisartan

Certificado de análise (CofA)

current certificate can be downloaded

embalagem

pkg of 500 mg

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C

InChI

1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)

chave InChI

RMMXLENWKUUMAY-UHFFFAOYSA-N

Informações sobre genes

human ... AGTR1(185)

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Descrição geral

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Telmisartan belongs to the class of angiotensin II receptor antagonists (ARAs) used in the treatment of hypertension.

Aplicação

This pharmaceutical secondary standard can also be used as follows:
  • Reversed-phase high-performance liquid chromatography (RP-HPLC) method-based multi-analysis of rosuvastatin, telmisartan, ezetimibe, and atorvastatin in pharmaceutical dosage formulations
  • RP-HPLC analysis of telmisartan in the presence of its three impurities in its tablet formulation following an analytical quality-by-design (AQbD) approach
  • Multi-determination of hydrochlorothiazide, amlodipine, and telmisartan by HPLC combined with spectrometric techniques without derivatization
  • Simultaneous estimation of telmisartan and hydrochlorothiazide by micellar high-pressure liquid chromatography and spectrophotometry-based methods in their combined tablet formulations
  • RP-HPLC method-based determination of four cardiovascular drugs—atorvastatin, simvastatin, telmisartan, and irbesartan in bulk drugs and tablet dosage forms, following ICH guidelines

Ações bioquímicas/fisiológicas

Telmisartan is a non-peptide AT1 angiotensin receptor antagonist.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC3179 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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AQbD-oriented development of a new LC method for simultaneous determination of telmisartan and its impurities
Dobricic V, et al.
Chromatographia, 80, 1199-1209 (2017)
Chemometric technique for the optimization of chromatographic system: Simultaneous HPLC determination of Rosuvastatin, Telmisartan, Ezetimibe and Atorvastatin used in combined cardiovascular therapy
Janardhanan VS, et al.
Arabian Journal of Chemistry, 9, S1378-S1387 (2016)

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