PHR1143

Lisinopril

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): (S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dihydrate, MK-521
• Fórmula empírica (Notação de Hill): C₂₁H₃₁O₅N₃ · 2H₂O
• Número CAS: 83915-83-7
• Peso molecular: 441.52
• Número MDL: MFCD01698825
• Código UNSPSC: 41116107
• ID de substância PubChem: 329823163
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to BP 695; traceable to Ph. Eur. L0702000; traceable to USP 1368609
• família API: lisinopril
• Certificado de análise (CofA): current certificate can be downloaded
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: 2-30°C
• cadeia de caracteres SMILES: [H]O[H].[H]O[H].NCCCC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
• chave InChI: CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
• Informações sobre genes: human ... ACE(1636)

Descrição

Descrição geral

Lisinopril is a lysine derivative of enalaprilat and belongs to the group of angiotensin converting enzyme (ACE) inhibitors. It is widely used as an orally active medication in the treatment of high blood pressure and may be used to treat congestive heart failure.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Lisinopril may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using kinetic spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Angiotensin converting enzyme (ACE) inhibitor.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAB3302 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360D,H373
• Declarações de precaução: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 1A - STOT RE 2
• Órgãos-alvo: Kidney
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable