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Key Documents

PHR1549

Supelco

1,4-Dioxano

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Dioxano, Óxido de etileno

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About This Item

Fórmula empírica (Notação de Hill):
C4H8O2
Número CAS:
Peso molecular:
88.11
Beilstein:
102551
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to USP 1601521

densidade de vapor

3 (vs air)

pressão de vapor

27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

Certificado de análise (CofA)

current certificate can be downloaded

temperatura de autoignição

356 °F

Lim. expl.

22 %

embalagem

ampule of 3x1.2 mL each

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

índice de refração

n20/D 1.422 (lit.)

pb

100-102 °C (lit.)

pf

10-12 °C (lit.)

densidade

1.034 g/mL at 25 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

chave InChI

RYHBNJHYFVUHQT-UHFFFAOYSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

1,4-Dioxane belongs to the class of volatile organic compounds (VOCs).
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

1,4-Dioxane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk pharmaceuticals, and cosmetic raw materials and finished products by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC0289 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Perigos de suplementos

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

51.8 °F - closed cup

Ponto de fulgor (°C)

11 °C - closed cup


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Certificados de análise (COA)

Lot/Batch Number

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Sigma-Aldrich

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Sigma-Aldrich

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Supelco

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Black RE, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 84(3), 666-670 (2001)
A capillary gas chromatographic procedure for the analysis of nine common residual solvents in water-insoluble bulk pharmaceuticals
Li QC, et al.
Journal of Chromatographic Science, 36(3), 119-124 (1998)
Establishment of a knowledge base for prescreening residual solvents in pharmaceuticals
Qin L, et al.
Chromatographia, 59(7-8), 475-480 (2004)
Simultaneous determination of 22 volatile organic compounds, methyl-tert-butyl ether, 1, 4-dioxane, 2-methylisoborneol and geosmin in water by headspace solid phase microextraction-gas chromatography-mass spectrometry
Nakamura S and Daishima S
Analytica Chimica Acta, 548(1-2), 79-85 (2005)
Joshua J Pacheco et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8363-8367 (2014-06-10)
Terephthalic acid (PTA), a monomer in the synthesis of polyethylene terephthalate (PET), is obtained by the oxidation of petroleum-derived p-xylene. There is significant interest in the synthesis of renewable, biomass-derived PTA. Here, routes to PTA starting from oxidized products of

Protocolos

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

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