PHR1432

N-Acetil-D-glicosamina

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): 2-Acetamido-2-desoxi-D-glicose, D-GlcNAc
• Fórmula empírica (Notação de Hill): C₈H₁₅NO₆
• Número CAS: 7512-17-6
• Peso molecular: 221.21
• Beilstein: 1727589
• Número MDL: MFCD00061615
• Código UNSPSC: 41116107
• ID de substância PubChem: 329822596
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to USP 1010022
• família API: glucosamine
• Certificado de análise (CofA): current certificate can be downloaded
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• pf: 211 °C (dec.) (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: 2-30°C
• cadeia de caracteres SMILES: CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
• InChI: 1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1
• chave InChI: OVRNDRQMDRJTHS-RTRLPJTCSA-N

Descrição

Descrição geral

N-Acetylglucosamine (GlcNAc) is a monosaccharide, derived from glucose and undergoes linear polymerization by (1,4)-β-linkages to form the polymer chitin. It is also a component of heterogenous polysaccharides, such as murein and hyaluronic acid. N-acetylglucosamine exhibits anti-inflammatory properties and is considered as a potential drug in the treatment of osteoarthritis. Its antiarthritic mode of mechanism involves the suppression of IL-1β (Interleuken-1β)-induced NO (nitric oxide), cyclooxygenase-2 (COX-2), and IL-6 production by inhibition of expression of iNOS (inducible nitric oxide synthase) protein and mRNA.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

N-Acetylglucosamine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric, chromatographic, and electrophoretic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC3267 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable