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M8277

Supelco

Midodrine hydrochloride

analytical standard, for drug analysis

Sinônimo(s):

(±)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol

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About This Item

Fórmula empírica (Notação de Hill):
C12H18N2O4 · HCl
Número CAS:
3092-17-9
Peso molecular:
290.74
Número MDL:
MFCD00079455
Código UNSPSC:
41116107
ID de substância PubChem:
329818055
NACRES:
NA.24

grau

analytical standard, for drug analysis

Nível de qualidade

100

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Formato

neat

cadeia de caracteres SMILES

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

InChI

1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

chave InChI

MGCQZNBCJBRZDT-UHFFFAOYSA-N

Informações sobre genes

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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Descrição geral

Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.

Aplicação

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ações bioquímicas/fisiológicas

α-Adrenergic agonist; vasoconstrictor

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P301 + P310

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
BCCF0296
BCCD3381
BCBW4710
BCBT9587
BCBR4789

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J M Soler et al.
European journal of physical and rehabilitation medicine, 47(4), 677-681 (2012-01-10)
Spinal cord injury (SCI) is associated with impaired ejaculation. After SCI, more stimuli may be required to trigger what remains of sexual reflexes. Penile vibratory stimulation (PVS) induces a strong afferent nerve stimulation and intense activation of the autonomic nervous
Jacobus J C M Romme et al.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 13(11), 1639-1647 (2011-07-15)
Initial treatment of vasovagal syncope (VVS) consists of advising adequate fluid and salt intake, regular exercise, and physical counterpressure manoeuvres. Despite this treatment, up to 30% of patients continue to experience regular episodes of VVS. We investigated whether additional Midodrine
Jill M Wecht et al.
Archives of physical medicine and rehabilitation, 92(11), 1789-1795 (2011-07-19)
To compare responses to head-up tilt (HUT) in individuals with chronic tetraplegia after midodrine hydrochloride (10 mg) versus nitro-L-arginine methyl ester (L-NAME, 1 mg/kg) administration. Prospective comparative drug trial. Veterans Affairs medical center. Participants (N=7) were studied during 3 laboratory
Khurram Bari et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 10(10), 1169-1175 (2012-07-18)
Large-volume paracentesis (LVP) is the treatment of choice for patients with cirrhosis and refractory ascites. However, LVP can lead to postparacentesis circulatory dysfunction (PCD), which is associated with faster ascites recurrence and renal failure. PCD results from vasodilatation, which reduces
Douglas Z Liou et al.
Chest, 144(3), 1055-1057 (2013-09-07)
Thoracic duct injury is a rare but serious complication following surgery of the neck or chest that leads to uncontrolled chyle leak. Conventional management includes drainage, nutritional modification, or aggressive surgical interventions such as thoracic duct ligation, flap coverage, fibrin
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