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Documentos Principais

32161

Supelco

Gamithromycin

VETRANAL®, analytical standard

Sinônimo(s):

(2R,3S,4R,5S,8RR,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylohexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one

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About This Item

Fórmula empírica (Notação de Hill):
C40H76N2O12
Número CAS:
Peso molecular:
777.04
Número MDL:
Código UNSPSC:
41116107
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

linha de produto

VETRANAL®

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

forensics and toxicology
veterinary

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

N1([C@@H](C[C@]([C@@H](C([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C1)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O[C@@H]2O[C@@H](C[C@@H]([C@H]2O)N(C)C)C)(O)C)C)CCC

InChI

1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25?,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1

chave InChI

VWAMTBXLZPEDQO-FWEXOAGLSA-N

Descrição geral

Gamithromycin is a drug, which is administered to cattle for the treatment of bovine respiratory disease caused by Pasteurella multocida, Histophilus somni and Mannheimia haemolytica. It is also effective in treating certain infections caused by Mycoplasma.

Aplicação

Gamithromycin may be used as a reference standard in the determination of gamithromycin in samples of plasma, lung tissue and pulmonary epithelial lining fluid using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informações legais

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Health hazardExclamation mark

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Os clientes também visualizaram

Slide 1 of 7

1 of 7

Michal Beker et al.
Frontiers in microbiology, 9, 1329-1329 (2018-07-13)
Strains of the Pasteurellaceae bacteria Pasteurella multocida and Mannheimia haemolytica are major etiological agents of bovine respiratory disease (BRD). Treatment of BRD with antimicrobials is becoming more challenging due to the increasing occurrence of resistance in infecting strains. In Pasteurellaceae
Development and validation of a liquid chromatography?tandem mass spectrometry method for the quantitative determination of gamithromycin in animal plasma, lung tissue and pulmonary epithelial lining fluid.
Baere DS, et al.
Journal of Chromatography A, 1398, 73-82 (2015)
Jase J Ball et al.
Journal of animal science, 96(3), 890-901 (2018-02-01)
Crossbred beef bulls (n = 180) were blocked by initial BW (337 ± 10.9 kg; six blocks) and assigned randomly to one of three treatments on day 0: 1) INJ; received 1 mL (100 mg Zn) of a Zn solution
Michael Kellermann et al.
Research in veterinary science, 97(2), 199-203 (2014-09-23)
This study assessed the plasma kinetics and skin/plasma concentration ratio of the azalide antibiotic gamithromycin (ZACTRAN(®), Merial) in sheep after a single subcutaneous administration at 6 mg/kg bodyweight. Gamithromycin concentrations in plasma samples collected at various intervals up to 21
Saunders Handbook of Veterinary Drugs: Small and Large Animal (2015)

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