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Documentos Principais

16033

Sigma-Aldrich

1,2-Propanediol

meets analytical specification of Ph. Eur., BP, USP, ≥99.5%

Sinônimo(s):

1,2-PDO, Propylene glycol

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About This Item

Fórmula linear:
CH3CH(OH)CH2OH
Número CAS:
Peso molecular:
76.09
Beilstein:
1340498
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.21

densidade de vapor

2.62 (vs air)

Nível de qualidade

pressão de vapor

0.08 mmHg ( 20 °C)

Ensaio

≥99.5%

Formulário

liquid

temperatura de autoignição

779 °F

qualidade

meets analytical specification of Ph. Eur., BP, USP

prazo de validade

24 mo.

Lim. expl.

12.5 %

Impurezas

acidic reac. impurities, complies
organic volatile impurities, complies (GC)
oxidizing substances, complies
reducing matter, complies
residual solvents, complies
≤0.0005% heavy metals (as Pb)
≤0.002% free alkali (as NaOH)
≤0.003% free acid (as CH3COOH)
≤0.2% water (Karl Fischer)

resíduo de ignição

≤0.005% (as SO4)

índice de refração

n20/D 1.431-1.433
n20/D 1.432 (lit.)

p.e.

187 °C (lit.)

pf

−60 °C (lit.)

densidade

1.036 g/mL at 25 °C (lit.)

traços de ânion

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

adequação

complies for appearance of solution

grupo funcional

hydroxyl

cadeia de caracteres SMILES

CC(O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

chave InChI

DNIAPMSPPWPWGF-UHFFFAOYSA-N

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Descrição geral

1,2-Propanediol is an 1,2-alkanediol. It can be obtained from glycerol, via hydrogenolysis in the presence of Ru/C and Amberlyst ion-exchange resins.
1,2-Propanediol is an important petrochemical that can be prepared by the hydrogenolysis of glycerol. It is mainly used as a cryoprotectant for biological samples and also as an additive in food, cosmetic and pharmaceutical industries.

Aplicação

1,2-Propanediol may be employed as a cryoprotective agent for the preservation (by cooling to sub-zero temperatures) of human embryos and and oocytes (human and mouse).

Embalagem

bottled under inert gas

Outras notas

The article number 16033-4X5L will be discontinued. Please order the single bottle 16033-5L which is physically identical with the same exact specifications.
The article number 16033-6X1L will be discontinued. Please order the single bottle 16033-1L which is physically identical with the same exact specifications.
The article number 16303-4X2.5L-R will be discontinued. Please order the single bottle 16303-2.5L-R which is physically identical with the same exact specifications.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

219.2 °F - closed cup

Ponto de fulgor (°C)

104 °C - closed cup

Equipamento de proteção individual

Eyeshields, Gloves


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Aqueous phase hydrogenolysis of glycerol to 1, 2-propanediol without external hydrogen addition.
Roy D, et al.
Catalysis Today, 156(1), 31-37 (2010)
D A Gook et al.
Human reproduction (Oxford, England), 8(7), 1101-1109 (1993-07-01)
Human and mouse oocytes were cryopreserved by a slow freeze, rapid thaw method, using propanediol (PROH) as the cryoprotectant. A simulated cryopreservation was also included in the study to detect the level of damage attributable to the PROH alone. Comparison
Glycerol hydrogenolysis to 1, 2-propanediol catalyzed by a heat-resistant ion-exchange resin combined with Ru/C.
Miyazawa T, et al.
Applied Catalysis A: General, 329, 30-35 (2007)
B Lassalle et al.
Fertility and sterility, 44(5), 645-651 (1985-11-01)
Eighty-five human embryos fertilized in vitro were frozen and thawed with 1,2 propanediol as a cryoprotective agent. The effects of viability of in vitro culture duration, stage, and morphologic appearance of embryos were examined after thawing. Survival was higher for
Yusha Imtiaz et al.
Nanomaterials (Basel, Switzerland), 10(8) (2020-08-23)
Polysaccharides have been shown to have immunomodulatory properties. Modulation of the immune system plays a crucial role in physiological processes as well as in the treatment and/or prevention of autoimmune and infectious diseases. Cellulose nanocrystals (CNCs) are derived from cellulose

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