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11126

Sigma-Aldrich

Potassium antimonyl tartrate trihydrate

puriss., meets analytical specification of USP, 99.0-103.0%, powder

Sinônimo(s):

Antimony potassium tartrate trihydrate, Tartar emetic

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About This Item

Fórmula empírica (Notação de Hill):
C8H4K2O12Sb2 · 3H2O
Número CAS:
28300-74-5
Peso molecular:
667.87
Número CE:
234-293-3
Número MDL:
MFCD00167056
Código UNSPSC:
12352100
ID de substância PubChem:
57646885
NACRES:
NA.21

grau

puriss.

Nível de qualidade

200

Ensaio

99.0-103.0%

forma

powder

qualidade

meets analytical specification of USP

Impurezas

≤0.02 mmol/g free acid
≤0.02 mmol/g free alkali

perda

≤2.7% loss on drying, 105 °C

pf

≥300 °C (lit.)

traços de cátion

As: ≤150 mg/kg
Pb: ≤20 mg/kg

cadeia de caracteres SMILES

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

chave InChI

WBTCZEPSIIFINA-UHFFFAOYSA-J

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Descrição geral

Potassium antimonyl tartrate trihydrate is a trivalent antimonial compound. It has been reported to be more toxic than pentavalent antimony (Pentostam) against Leishmania species. Its crystal structure has been investigated by the three-dimensional X-ray and white radiation neutron diffraction techniques. It crystallizes in space group C2221. Unit cell dimensions reported were: a = 11.192(2), b = 11.696(3), and c = 25.932(5)Å.

Aplicação

Potassium antimonyl tartrate trihydrate was employed as an Sb(III)-containing drug to investigate its ability to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum†
It may also be used as a standard solution to determine the metalloid concentration such as Sb(III) and Sb(V) in surface soil, using high performance liquid chromatography coupled to inductively coupled plasma-mass spectrometry (HPLC-ICP-MS).

Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palavra indicadora

Danger

Frases de perigo

H301,H315,H317,H332,H411

Classificações de perigo

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

Código de classe de armazenamento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCCG6808
BCCG6346
BCCG2737
BCCC8607
BCBZ5634

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"A study of antimony complexed to soil-derived humic acids and inorganic antimony species along a Massachusetts highway"
Ceriotti G and Amarasiriwardena D
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 91(01), 85-93 (2009)
D Sereno et al.
Antimicrobial agents and chemotherapy, 45(7), 2064-2069 (2001-06-16)
The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several
X-ray and white radiation neutron diffraction studies of optically active potassium antimony tartrate, K2Sb2(dC4H2O6)2? 3H2O (tarter emetic).
Gress ME and Jacobson RA.
Inorgorganica Chimica Acta, 8, 209-217 (1974)
D Sereno et al.
Antimicrobial agents and chemotherapy, 42(12), 3097-3102 (1998-12-03)
The mechanism(s) of activity of pentavalent antimony [Sb(V)] is poorly understood. In a recent study, we have shown that potassium antimonyl tartrate, a trivalent antimonial [Sb(III)], was substantially more potent than Sb(V) against both promastigotes and axenically grown amastigotes of
Susan Wyllie et al.
Biochemical pharmacology, 71(3), 257-267 (2005-12-02)
Trivalent antimonial compounds (Sb(III)), originally used in the treatment of leishmaniasis, are now being proposed as a novel therapy for acute promyelocytic leukaemia (APL). Here, we examine the effects of Sb(III) and pentavalent antimonial drugs (Sb(V)) on glutathione homeostasis, oxidative
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