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Key Documents

MAB5284

Sigma-Aldrich

Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301

clone Cat-301, Chemicon®, from mouse

Sinônimo(s):

CSPG

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

Cat-301, monoclonal

reatividade de espécies

primate, human, rat, gerbil, feline, hamster, guinea pig

fabricante/nome comercial

Chemicon®

técnica(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ACAN(176)

Descrição geral

The antigen recognized by this clone, CAT-301 is a proteoglycan that is developmentaly regulated, high molecular chondroitin sulphate proteoglycan found on the extracellular surface of mammalian neurons. It is expressed late in development and although no definitive role has been identified for CAT-301, it is believed to have a role in the stabilisation of synaptic structure.

The name derives from the name of the monoclonal antibody originally used to identified by its expression, which was detected immunocytochemicaly



Disruption of the normal patterns of neuronal activity during the critical early postnatal period by physical or biochemical means results in a large and irreversible reduction in levels of CAT-301. Similar intervention in mature animals has no effect



CAT-301 is related to aggrecan from articular cartilage. The CAT-301 antibody immunoreacts with aggrecan, and the chondroitinase treated aggrecan and CAT-301 both have apparent sizes of 550kDa. However CAT- 301 is not glycosylated by keratan sulphate, as aggrecan is.

Especificidade

Chondroitin sulfate proteoglycan (CSPG), brain core protein.

Imunogênio

Epitope: Brain (core protein)
Feline spinal cord fixed gray matter.

Aplicação

Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301 detects level of Chondroitin Sulfate Proteoglycan & has been published & validated for use in IP, WB, IC, IH.
Immunohistochemistry: 1:500-1:2,000 on 4% paraformaldehyde fixed frozen tissue.

Immunocytochemistry

Immunoblot

Immunoprecipitation

Optimal working dilutions must be determined by the end user.

forma física

Format: Purified

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Differential expression of several molecules of the extracellular matrix in functionally and developmentally distinct regions of rat spinal cord.
Laura Vitellaro-Zuccarello,Paola Bosisio,Samanta Mazzetti,Claudia Monti,Silvia De Biasi
Cell and Tissue Research null
A surface antigen that identifies ocular dominance columns in the visual cortex and laminar features of the lateral geniculate nucleus.
Hockfield, S, et al.
Cold Spring Harbor Symposia on Quantitative Biology, 48 Pt 2, 877-889 (1983)
Histochemical differences between motoneurons supplying multiply and singly innervated extraocular muscle fibers.
Andreas C Eberhorn, Patricia Ardeleanu, Jean A Buttner-Ennever, Anja K E Horn
The Journal of Comparative Neurology null
A surface antigen expressed by a subset of neurons in the vertebrate central nervous system.
Hockfield, S and McKay, R D
Proceedings of the National Academy of Sciences of the USA, 80, 5758-5761 (1983)
A C Eberhorn et al.
Neuroscience, 137(3), 891-903 (2005-12-07)
In mammals, the extraocular muscle fibers can be categorized in singly-innervated and multiply-innervated muscle fibers. In the monkey oculomotor, trochlear and abducens nucleus the motoneurons of multiply-innervated muscle fibers lie separated from those innervating singly-innervated muscle fibers and show different

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