MAB3482
Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, clone MM13-4
clone MM13-4, Chemicon®, from mouse
Sinônimo(s):
CFTR
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
MM13-4, monoclonal
reatividade de espécies
human
não deve reagir com
mouse, shark
fabricante/nome comercial
Chemicon®
técnica(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG1
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CFTR(1080)
Especificidade
Human cystic fibrosis transmembrane conductance regulator (CFTR). Recognizes an epitope at the N-terminal between residues 24 and 35.
Imunogênio
Synthetic peptide (RKGYRQRLELSD) corresponding to residues 25-36 of human cystic fibrosis transmembrane conductance regulator (CFTR).
Aplicação
Detect Cystic Fibrosis Transmembrane Conductance Regulator using this Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, clone MM13-4 validated for use in IC, IP & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Western blot: 10 μg/mL, recognizes CFTR (150-170kDa) and two additional proteins at 52kDa and 38kDa
Immunoprecipitation
Immunofluorescence
Note: Does not work on paraffin embedded tissue.
Optimal working dilutions must be determined by the end user.
Immunoprecipitation
Immunofluorescence
Note: Does not work on paraffin embedded tissue.
Optimal working dilutions must be determined by the end user.
forma física
Format: Purified
Purified immunoglobulin. Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide.
Armazenamento e estabilidade
Maintain at 2-8°C in undiluted aliquots up to 6 months.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Nº do produto
Descrição
Preços
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Ion transport mechanisms linked to bicarbonate secretion in the esophageal submucosal glands.
Abdulnour-Nakhoul, S; Nakhoul, HN; Kalliny, MI; Gyftopoulos, A; Rabon, E; Doetjes et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology null
Shipeng Wei et al.
The Journal of biological chemistry, 289(29), 19942-19957 (2014-05-31)
ATP-binding cassette (ABC) transporters are an ancient family of transmembrane proteins that utilize ATPase activity to move substrates across cell membranes. The ABCC subfamily of the ABC transporters includes active drug exporters (the multidrug resistance proteins (MRPs)) and a unique
Nabila Hamdaoui et al.
British journal of pharmacology, 163(4), 876-886 (2011-03-04)
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent chloride channel in the plasma membrane of epithelia whose mutation is the cause of the genetic disease cystic fibrosis (CF). The most frequent CFTR mutation is deletion of Phe(508) and
Lianwu Fu et al.
The Biochemical journal, 441(2), 633-643 (2011-10-15)
CFTR (cystic fibrosis transmembrane conductance regulator) is expressed in the apical membrane of epithelial cells. Cell-surface CFTR levels are regulated by endocytosis and recycling. A number of adaptor proteins including AP-2 (μ2 subunit) and Dab2 (Disabled-2) have been proposed to
Jie Ting Zhang et al.
Scientific reports, 7(1), 5233-5233 (2017-07-14)
Cystic fibrosis transmembrane conductance regulator (CFTR), known as a cAMP-activated Cl- channel, is widely expressed at the apical membrane of epithelial cells in a wide variety of tissues. Of note, despite the abundant expression of CFTR in mammalian kidney, the
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