MAB3328
Anti-MMP-14 Antibody, catalytic domain, clone LEM-2/15.8
clone LEM-2/15.8, Chemicon®, from mouse
Sinônimo(s):
MT1-MMP
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
LEM-2/15.8, monoclonal
reatividade de espécies
mouse, human
embalagem
antibody small pack of 25 μg
fabricante/nome comercial
Chemicon®
técnica(s)
ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG1κ
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
ambient
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... MMP14(4323)
Descrição geral
MT1-MMP plays an important role during endothelial cell migration and matrix remodeling. Although the role of MT1-MMP in endothelial cell motility is not fully characterized, its activity appears to modulate endothelial migration, invasion, and formation of capillary tubes during the angiogenic response (Galvez, 2001). Mt1-MMP also appears to play a key role in monocyte revruitment during inflammation (Salomon, 2005).
Especificidade
LEM-2/15.8 reacts with human MT1-MMP and displays crossreactivity with mouse specimens. This antibody was generated against the catalytic domain of MT1-MMP and is able to inhibit enzyme activity.
Imunogênio
Epitope: catalytic domain
Synthetic peptide: amino acid sequence 218-233 within the catalytic domain
Aplicação
Detect MMP-14 using this Anti-MMP-14 Antibody, catalytic domain, clone LEM-2/15.8 validated for use in ELISA, IP & WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
MMPs & TIMPs
MMPs & TIMPs
Western Blot
Immunohistochemistry: Frozen and paraffin-embedded tissues
Immunofluorescence
Flow Cytometry
Blocking: 10-15μg/mL
Optimal working dilutions must be determined by the end user.
Immunohistochemistry: Frozen and paraffin-embedded tissues
Immunofluorescence
Flow Cytometry
Blocking: 10-15μg/mL
Optimal working dilutions must be determined by the end user.
forma física
Format: Purified
Purified immunoglobulin by Protein A chromatography . Liquid in 0.2M phosphate, 0.25M NaCl, pH 7.6, containing 0.1% sodium azide.
Armazenamento e estabilidade
Maintain at 2° to 8°C for up to 12 months from date of receipt.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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recomendado
Nº do produto
Descrição
Preços
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration.
Williams, BB; Cantrell, VA; Mundell, NA; Bennett, AC; Quick, RE; Jessen, JR
Journal of Cell Science null
Sodium fluoride induces podosome formation in endothelial cells.
Tatin, Florence, et al.
Biology of the Cell, 102, 489-498 (2010)
J K Björk et al.
Oncogene, 35(14), 1770-1784 (2015-06-30)
Heat-shock factors (HSFs) are key transcriptional regulators in cell survival. Although HSF1 has been identified as a driver of carcinogenesis, HSF2 has not been explored in malignancies. Here, we report that HSF2 suppresses tumor invasion of prostate cancer (PrCa). In
Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration.
Nyalendo, C; Michaud, M; Beaulieu, E; Roghi, C; Murphy, G; Gingras, D; Beliveau, R
The Journal of Biological Chemistry null
KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages.
Wiesner, Christiane, et al.
Blood, 116, 1559-1569 (2010)
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