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Key Documents

ABT1382

Sigma-Aldrich

Anti-Neurocan

from rabbit

Sinônimo(s):

Neurocan core protein, 245 kDa early postnatal core glycoprotein, Chondroitin sulfate proteoglycan 3

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

unpurified

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

rat

embalagem

antibody small pack of 25 μL

técnica(s)

immunofluorescence: suitable

Isotipo

IgG

nº de adesão UniProt

Condições de expedição

ambient

modificação pós-traducional do alvo

unmodified

Informações sobre genes

rat ... Ncan(58982)

Descrição geral

Neurocan core protein (UniProt: P55067; also known as 245 kDa early postnatal core glycoprotein, Chondroitin sulfate proteoglycan 3) is encoded by the Ncan (also known as Cspg3) gene in rat. Neurocan is a secreted protein of the aggrecan/versican proteoglycan family that is found in early postnatal and adult brain. During early postnatal development neurocan accounts for at least 20% of the protein of the soluble brain proteoglycans. Neurocan mostly contains chondroitin sulfate, but also has N-linked and O-linked oligosaccharides. It is shown to be involved in the modulation of cell adhesion and migration and regulates neurite outgrowth. Neurocan interact with several cell surface molecules, such as N-CAM, L1/Ng-CAM, etc., and modulates the cell-binding and neurite outgrowth promoting activates of these molecules. Neurocan is synthesized with a 22 aa signal peptide that is subsequently cleaved to produce the mature form. Neurocan contains one C-type lectin domain, two EGF-like domains, one Ig-like V type domain, two link domains and one Sushi (CCP/SCR) domain. (Ref.: Rauch, U., et al. (2001) Cell Mol. Life Sci. 58(12-13):1842-56; Zhou, XH et al. (2001). Mol. Cell Biol. 21(17): 5970-78).

Especificidade

This rabbit polyclonal antibody detects Neurocan in fetal and adult rat brain.

Imunogênio

Epitope: unknown
Full-length Neurocan isolated from 7-day embryonic rat brain and purified by monoclonal antibody immunoaffinity chromatography.

Aplicação

Research Category
Cell Structure
This rabbit polyclonal Anti-Neurocan, Cat. No. ABT1382, is a rabbit polyclonal antibody that detects Neurocan core protein and has been tested for use in Immunofluorescence.

Qualidade

Evaluated by Immunofluorescence in E14 embryonic rat brain (frozen sections) and adult rat brain (frozen sections).

Immunofluorescence Analysis: A 1:500 dilution of this antibody detected Neurocan in E14 embryonic rat brain (frozen sections) and rat E14 neocortex.

Descrição-alvo

135.55 kDa calculated.

forma física

Format: Unpurified
Rabbit polyclonal antiserum with 0.05% sodium azide.
Unpurified

Armazenamento e estabilidade

Stable for 1 year at -20°C from date of receipt.

Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1


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