ABS2120

Anti-methylglutaryl-lysine

from rabbit

• Sinônimo(s): 3-methylglutaryl (MG)-lysine, MG
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• reatividade da espécie (prevista por homologia): all
• embalagem: antibody small pack of 25 μg
• técnica(s): western blot: suitable
• Isotipo: IgG
• modificação pós-traducional do alvo: unmodified

Descrição

Descrição geral

Acetylation of lysine residues is proteins has emerged as an important mechanism in regulation and coordination of normal and pathophysiological cell metabolism. Lysine 3-methylglutaryl is a newer post-translational protein modification that occurs under normal basal conditions. In murine models of HMG-CoA lyase deficiency, higher levels of protein lysine 3-MGylation are observed. This rabbit polyclonal antibody specifically detects chemically modified proteins containing 3-methylglutaryl lysine modifications, but not unmodified proteins. (Ref.: Wagner, GR et al. (2017). Cell Metabolism 25(4); 823-837).

Especificidade

This rabbit polyclonal antibody detects 3-methylglutaryl (MG)-lysine conjugated to BSA.

Imunogênio

3-methylglutaryl (MG)-lysine conjugated to BSA.

Aplicação

Anti-methylglutaryl-lysine, Cat. No. ABS2120, is a rabbit polyclonal antibody that detects 3-methylglutaryl-lysine conugated proteins and has been tested for use in Western Blotting.

Research Category
Signaling

Western Blotting Analysis: A representative lot detected methylglutaryl-lysine in Western Blotting applications (Wagner, G.R., et. al. (2017). Cell Metab. 25(4):823-837; Anderson, K.A., et. al. (2017). Cell Metab. 25(4):838-855.e15).

Qualidade

Evaluated by Western Blotting with methyl glutaryl BSA conjugate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected 3-methylglutaryl (MG)-lysine in methyl glutaryl BSA conjugate.

Descrição-alvo

~75 kDa observed (BSA conjugate). Uncharacterized bands may be observed in some lysate(s).

forma física

Affinity Purified

Format: Purified

Purified rabbit polyclonal antibody in PBS with 0.1% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.