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Documentos Principais

ABN60

Sigma-Aldrich

Anti-Tryptophan hydroxylase 2 Antibody

from rabbit, purified by affinity chromatography

Sinônimo(s):

tryptophan hydroxylase 2, Tryptophan 5-monooxygenase 2, Neuronal tryptophan hydroxylase, tryptophan 5-hydroxylase 2

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

human, rat

reatividade da espécie (prevista por homologia)

mouse (immunogen homology)

técnica(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... TPH2(121278)

Descrição geral

Tryptophan hydroxylase 2 (TPH2) is preferentially expressed in the brain and is thought to play an important role in serotonin synthesis. Recent research has actually associated high levels of TPH2 with risk of suicide. Misfolding of TPH2 may be the cause of a loss of serotonin neuronal function in Parkinson’s disease. Detection and screening of particular mutations in TPH2 has been cited as an approach toward predicting patient sensitivity to potential antidepressant therapies and even the possibility of diagnosis of behavioral disorders.

Imunogênio

KLH-conjugated linear peptide corresponding to human Tryptophan hydroxylase 2.

Aplicação

Anti-Tryptophan hydroxylase 2 Antibody detects level of Tryptophan hydroxylase 2 & has been published & validated for use in WB, IH(P).
Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Tryptophan hydroxylase 2 in rat cerebral cortex tissue.
Research Category
Neuroscience
Research Sub Category
Signaling Neuroscience

Qualidade

Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected Tryptophan hydroxylase 2 on 10 µg of rat brain tissue lysate.

Descrição-alvo

~56 kDa observed

forma física

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Nota de análise

Control
Rat brain tissue lysate

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Lauren J Donovan et al.
eLife, 8 (2019-07-30)
Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question by studying the formation of mouse serotonin (5-HT)
Mammalian-specific sequences in pou3f2 contribute to maternal behavior.
Nasu, M; Yada, S; Igarashi, A; Sutoo, D; Akiyama, K; Ito, M; Yoshida, N; Ueda, S
Genome Biology and Evolution null
Xinrui L Zhang et al.
eLife, 11 (2022-04-27)
Assembly of transcriptomes encoding unique neuronal identities requires selective accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded postmitotic chromatin. Yet, the mechanisms controlling postmitotic neuronal chromatin accessibility are poorly understood. Here, we show that unique distal enhancers define the
Yunju Jin et al.
Neuron, 91(4), 748-762 (2016-08-09)
It is widely believed that damaged axons in the adult mammalian brain have little capacity to regrow, thereby impeding functional recovery after injury. Studies using fixed tissue have suggested that serotonin neurons might be a notable exception, but remain inconclusive.
Tanya L Daigle et al.
Cell, 174(2), 465-480 (2018-07-17)
Modern genetic approaches are powerful in providing access to diverse cell types in the brain and facilitating the study of their function. Here, we report a large set of driver and reporter transgenic mouse lines, including 23 new driver lines

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