8.00907

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

• Sinônimo(s): N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
• Fórmula empírica (Notação de Hill): C₈H₁₇N₃ · xHCl
• Número CAS: 25952-53-8
• Peso molecular: 155.24 (free base basis)
• Número MDL: MFCD00012503
• Código UNSPSC: 12352107
• Número do índice EC: 247-361-2
• NACRES: NA.22

Propriedades

• product name: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis
• Nível de qualidade: 200
• forma: solid
• adequação da reação: reaction type: Coupling Reactions
• pf: 110-115 °C
• aplicação(ões): peptide synthesis
• temperatura de armazenamento: −20°C (−15°C to −25°C)
• InChI: 1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
• chave InChI: FDXPUDRRFDHONO-UHFFFAOYSA-N

Descrição

Descrição geral

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

Aplicação

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:

• A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
• A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
• A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.

Informações de segurança

• Pictogramas: GHS06,GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H302 - H311 - H315 - H317 - H373 - H410
• Declarações de precaução: P260 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P314
• Classificações de perigo: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Código de classe de armazenamento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable