648493-M

TRPML Agonist, ML-SA1

The TRPML Agonist, ML-SA1 controls the biological activity of TRPML. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Sinônimo(s): TRPML Agonist, ML-SA1, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1, ML-SA1
• Fórmula empírica (Notação de Hill): C₂₂H₂₂N₂O₃
• Número CAS: 332382-54-4
• Peso molecular: 362.42
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• Formulário: powder
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: off-white
• solubilidade: DMSO: 25 mg/mL
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
• chave InChI: KDDHBJICVBONAX-UHFFFAOYSA-N

Descrição

Descrição geral

A membrane permeable dihydroquinolinyloxo-isoindolinedione compound that acts as a potent and selective agonist of lysosomal mucolipin transient receptor potential (TRP) channel 1,2,3 (TRPML) in all mammalian cells. Does not appear to affect six other related TRP channels. Shown to rapidly activate whole-endolysosome TRPML-like current and induce lysosomal Ca²⁺ release (~10 µM). Its activating action on whole-endolysosome is comparable to that of PI(3,5)P2 (1 µM) with which it shows a synergistic effect. ML-SA1-induced Ca²⁺ responses are reportedly abolished by glycyl-L-phenylalanine 2-naphthylamide, induces osmotic lysis of lysosomes, and Bafilomycin A1 (>Cat. No. 196000), a V-ATPase inhibitor. Also reduces lactosylceramide and cholesterol accumulation and corrects trafficking defects in Niemann-Pick (NP) disease cells.

Ações bioquímicas/fisiológicas

Primary Target
TRPML1,2,3

Advertência

Toxicity: Standard Handling (A)

Outras notas

Shen, D., et al. 2012. Nat. Commun.3, 731.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable