648450-M

TrkA Inhibitor

The TrkA Inhibitor, also referenced under CAS 388626-12-8, controls the biological activity of TrkA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinônimo(s): TrkA Inhibitor
• Fórmula empírica (Notação de Hill): C₁₅H₁₃N₃O₃S
• Número CAS: 388626-12-8
• Peso molecular: 315.35
• Código UNSPSC: 12352200

Propriedades

• Ensaio: ≥97% (sum of two isomers, HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: DMSO: 200 mg/mL
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

A potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

An oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

Ações bioquímicas/fisiológicas

Primary Target
TrkA

Target IC₅₀: 63 nM against TrkA

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett.14, 953.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable