579050

TAPI-0

≥96% (HPLC), solid, collagenase, gelatinase, and TACE inhibitor, Calbiochem^®

• Sinônimo(s): TAPI-0, N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0
• Fórmula empírica (Notação de Hill): C₂₄H₃₂N₄O₅
• Número CAS: 143457-40-3
• Peso molecular: 456.53
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• product name: TAPI-0, TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM).
• Nível de qualidade: 100
• Ensaio: ≥96% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: white
• solubilidade: 50% acetic acid: 1 mg/mL; DMSO: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• InChI: 1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1
• chave InChI: CRCPLBFLOSEABN-VBSNWNEZSA-N

Descrição

Descrição geral

A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.

A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC₅₀ = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
TNF-α converting enzyme/ADAM17

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM against TACE (TNF-α converting enzyme/ADAM17)

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Outras notas

Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Mullberg, J., et al. 1995. J. Immunol.155, 5198.
Mohler, K.M., et al. 1994. Nature370, 218.

Informações legais

Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable