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Documentos Principais

566661

Sigma-Aldrich

SAG

≥95% (HPLC), liquid, smoothened agonist, Calbiochem®

Sinônimo(s):

InSolution Smoothened Agonist, SAG, SAG 1.3 in Solution, SAG1.3 in Solution

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About This Item

Fórmula empírica (Notação de Hill):
C28H28ClN3OS · 2HCl · xH2O
Peso molecular:
562.98 (anhydrous basis)
Código UNSPSC:
12352200
NACRES:
NA.77

Nome do produto

Smoothened Agonist, SAG, InSolution, ≥95%, 10 mM aqueous solution

Nível de qualidade

100

Ensaio

≥95% (HPLC)

Formulário

liquid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
protect from light

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Descrição geral

A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

forma física

A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.

Reconstituição

Following initial thaw, aliquot and freeze (-20°C).

Outras notas

Meloni, A.R., et al. 2006. Mol. Cell. Biol.26, 7750.
Chen, W., et al. 2004. Science306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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