557324

Riluzole

A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na⁺ channels.

• Sinônimo(s): Riluzole, 2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124
• Fórmula empírica (Notação de Hill): C₈H₅F₃N₂OS
• Número CAS: 1744-22-5
• Peso molecular: 234.20
• Número MDL: MFCD00210213
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• descrição: Merck USA index - 14, 8223
• Ensaio: ≥97% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white to off-white
• solubilidade: HCl: 0.1 N; DMSO: 40 mg/mL
• traços de cátion: heavy metals: ≤20 ppm
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: FC(F)(F)Oc1cc2[s]c(nc2cc1)N
• InChI: 1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
• chave InChI: FTALBRSUTCGOEG-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na⁺ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington′s disease (HD).

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Inhibits glutamate release and blocks Na+ channels

Product does not compete with ATP.

Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Toxic (F)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400.
Schiefer, J., et al. 2002. Mov. Disord.17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.
Mizoule, J., et al. 1985. Neuropharmacology24, 767.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 2 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3