551476

Q-VD-OPh, Non-O-methylated

≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem^®

• Sinônimo(s): InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
• Fórmula empírica (Notação de Hill): C₂₆H₂₅F₂N₃O₆
• Peso molecular: 513.49
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• product name: Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases
• Nível de qualidade: 100
• Ensaio: ≥90% (HPLC)
• forma: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively

Embalagem

Packaged under inert gas

Advertência

Toxicity: Irritant (B)

Sequência

Q-Val-Asp-CH₂-OPh

forma física

Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.

Reconstituição

Following initial thaw, aliquot and freeze (-20°C).

Outras notas

Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Ponto de fulgor (°C): 87 °C - closed cup - (Dimethylsulfoxide)