341501

FeTMPyP

Catalyzes the isomerization of peroxynitrite (ONOO⁻) to nitrate (NO3⁻) under physiological conditions and at realistic dose-derived concentrations (k_cat = 2.2 x 10⁶M⁻¹s⁻¹).

• Sinônimo(s): FeTMPyP, 5,10,15,20-Tetrakis(N-methyl-4ʹ-pyridyl)porphinato Iron (III) Chloride, Fe ^IIITMPyP(Cl)
• Fórmula empírica (Notação de Hill): C₄₄H₃₆Cl₅FeN₈
• Peso molecular: 909.92
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥90% (TLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: brown
• solubilidade: water: 50 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

Catalyzes the isomerization of peroxynitrite (ONOO^–) to nitrate (NO₃^–) under physiological conditions and at realistic dose-derived concentrations (K_cat = 2.2 x 10⁶ M^-1s^-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals (O₂^·). Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH·) radicals. FeTMPyP can also serve as a potential for drug detoxification of reactive oxygen species (ROS).

Catalyzes the isomerization of peroxynitrite (ONOO^-) to nitrate (NO₃^-) under physiological conditions and at realistic dose-derived concentrations (K_cat = 2.2 x 10⁶ M^-1s^-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also decomposes superoxide radicals (O₂^•) catalytically. Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH^•) radicals. FeTMPyP can also serve as a potential drug for reactive oxygen species (ROS) detoxification.

Ações bioquímicas/fisiológicas

Cell permeable: no

Kcat = 2.2 x 106 M-1s-1 in catalyzing the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions

Primary Target
Peroxynitrite (ONOO-)

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Outras notas

Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.46, 703.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable