328500

ERO1 Inhibitor I, Erodoxin

The ERO1 Inhibitor I, Erodoxin controls the biological activity of ERO1.

• Sinônimo(s): ERO1 Inhibitor I, Erodoxin, 1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor
• Fórmula empírica (Notação de Hill): C₇H₅BrN₂O₅
• Número CAS: 181995-71-1
• Peso molecular: 277.03
• Número MDL: MFCD00624873
• Código UNSPSC: 12352200
• NACRES: NA.28

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: DMSO: 100 mg/mL (Use only fresh DMSO)
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: BrC(C=C(C([N+]([O-])=O)=C1)OC)=C1[N+]([O-])=O

Descrição

Descrição geral

A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC₅₀ = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.

Outras notas

Costanzo, M., et al. 2010. Science327, 425.
Blais, J.D., et al. 2010. J. Biol. Chem.285, 20993.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable