324693

Emetine dihydrochloride

≥98% (HPLC), solid, protein synthesis blocker, Calbiochem^®

• Sinônimo(s): Emetine, Dihydrochloride, 6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
• Fórmula empírica (Notação de Hill): C₂₉H₄₀N₂O₄ · 2HCl
• Número CAS: 316-42-7
• Peso molecular: 553.56
• Número MDL: MFCD00242944
• Código UNSPSC: 41116107
• NACRES: NA.77

Propriedades

• Nome do produto: Emetine, Dihydrochloride, Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: white to off-white; white
• solubilidade: water: 20 mg/mL; ethanol: soluble
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [Cl-].[Cl-].N21[C@@H](C[C@@H]([C@H](C2)CC)C[C@H]4NCCc5c4cc(c(c5)OC)OC)c3c(cc(c(c3)OC)OC)CC1.[H+].[H+]
• InChI: 1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
• chave InChI: JROGBPMEKVAPEH-GXGBFOEMSA-N

Descrição

Descrição geral

Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC₅₀ ≤1 µM.

Principle alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC₅₀ ≤1 µM.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Movement of ribosomes along the mRNA

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity

Advertência

Toxicity: Highly Toxic (H)

Reconstituição

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kong, H.S., et al. 2010. Mol. Pharmacol.in press.
Khan, M.A. 1995. Prog. Neurobiol.46, 541.
Kokuho, T., et al. 1995. Immunobiology193, 42.
Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett.93, 157.
Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
Filley, E.A., and Rook, G.A. 1991. Infect. Immun.59, 2567.
Landis, R.C., et al. 1991. J. Immunol.146, 128.
Schweighoffer, T., et al. 1991. Histochemistry96, 93.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300,H315,H319
• Declarações de precaução: P264 - P270 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable