288500-M

DL-α-Difluoromethylornithine, Hydrochloride

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis.

• Sinônimo(s): DL-α-Difluoromethylornithine, Hydrochloride, DFMO, Eflornithine, RMI-71782
• Fórmula empírica (Notação de Hill): C₆H₁₂F₂N₂O₂ · xHCl · yH₂O
• Número CAS: 96020-91-6
• Peso molecular: 182.17 (anhydrous free base basis)
• Número MDL: MFCD00242734
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99% (HPLC)
• Formulário: powder
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white
• solubilidade: water: 1 mg/mL; methanol: 25 mg/mL
• temperatura de armazenamento: 10-30°C
• cadeia de caracteres SMILES: FC(F)C(N)(CCCN)C(=O)O.[Cl-].O.[H+]
• InChI: 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
• chave InChI: FJPAMFNRCFEGSD-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Ações bioquímicas/fisiológicas

Primary Target
ODC

Advertência

Toxicity: Carcinogenic / Teratogenic (D)

Reconstituição

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Meyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
Takigawa, M., et al. 1990. Cancer Res.50, 4131.
Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
Danzin, C., et al. 1979. Life Sci. 24, 519.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable