238811

Cdk9 Inhibitor II

The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinônimo(s): Cdk9 Inhibitor II, 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
• Fórmula empírica (Notação de Hill): C₉H₁₀N₆O
• Número CAS: 140651-18-9
• Peso molecular: 218.22
• Número MDL: MFCD09262258
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: orange
• solubilidade: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [nH]1nc(c(c1N)N=Nc2ccc(cc2)O)N
• InChI: 1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)
• chave InChI: AYZRKFOEZQBUEA-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC₅₀ = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC₅₀ = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Cdk9

Product competes with ATP.

Reversible: no

Target IC₅₀: 350 nM, using Cdk9/T1

Embalagem

Packaged under inert gas

Advertência

Toxicity: Irritant (B)

Outras notas

Krystof, V., et al. 2006. J. Med. Chem.49, 6500.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable