200488

Bestatin Hydrochloride

InSolution, ≥98%, a metalloprotease inhibitor

• Sinônimo(s): InSolutionBestatin, Hydrochloride, [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu, HCl
• Fórmula empírica (Notação de Hill): C₁₆H₂₄N₂O₄ · xHCl
• Peso molecular: 308.37 (free base basis)
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O.[xHCl]

Descrição

Descrição geral

A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Metalloproteases

Reversible: yes

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

forma física

Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.

Reconstituição

Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Outras notas

Merck Index: 14, 9842.
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable