14-628-M

TBK1 Protein, active, 10 µg

Active, N-terminal His6-tagged, recombinant, full length, human TBK1, for use in Kinase Assays.

• Sinônimo(s): NAK, NF-kappa-B-activating kinase, T2K, TANK-binding kinase-1
• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propriedades

• fonte biológica: human
• Nível de qualidade: 100
• recombinante: expressed in baculovirus infected Sf21 cells
• prazo de validade: 6 mo.
• peso molecular: M_w 85.7 kDa
• fabricante/nome comercial: Upstate^®
• técnica(s): activity assay: suitable (kinase)
• nº de adesão NCBI: NM_013254.2
• nº de adesão UniProt: Q9UHD2
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... TBK1(29110)

Descrição

Descrição geral

Research area: Cancer
Protein Target: TBK1, Target Sub-Family: Misc

TANK-binding kinase-1 (TBK1), also known as NF-κB activating kinase (NAK), is a serine-threonine kinase from the IκB kinase (IKK) family. It is encoded by tbk1 gene and is ubiquitously expressed in various tissues.

Aplicação

Research Category
Inflammation & Immunology

Ações bioquímicas/fisiológicas

TANK-binding kinase-1 (TBK1) is mainly involved in activating interferon regulatory transcription factor 3/7 (IRF 3/7) and nuclear factor (NF-κB) signaling pathways, which are essential for regulating the production of type I interferons (IFN), including IFN-α and IFN-β and the activation of innate immunity. In addition, TBK1 also mediates various other cellular processes including autophagy, proliferation, immune response/inflammation survival, insulin signaling, and metabolism. TBK1 plays a significant role in cancer pathogenesis. In cancer cells, it enhances tumor growth by activating proliferation and survival signaling, promoting tumor-promoting cytokine production, and facilitating the secretion of immunosuppressive inflammatory cytokines. Overexpression of tbk1 gene is observed in various cancers including non-small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDA), cholangiocarcinoma, clear cell renal cell carcinoma (ccRCC), adult T-cell leukemia, melanoma, esophageal cancer, and breast cancer.

Qualidade

routinely evaluated by phosphorylation of CK1tide (12-529)

forma física

Ni²⁺/NTA-agarose

Armazenamento e estabilidade

6 months at -70°C

Outras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.