106425

N-Acetyl-L-cysteine

Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock.

• Sinônimo(s): N-Acetyl-L-cysteine, LNAC
• Fórmula empírica (Notação de Hill): C₅H₉NO₃S
• Número CAS: 616-91-1
• Peso molecular: 163.19
• Número MDL: MFCD00004880
• Código UNSPSC: 12352209
• NACRES: NA.25

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥98% (titration)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: white
• solubilidade: water: 50 mg/mL
• traços de ânion: chloride (Cl^-): ≤0.04%; sulfate (SO₄^2-): ≤0.03%
• traços de cátion: Fe: ≤20 ppm
• Condições de expedição: ambient
• temperatura de armazenamento: 15-25°C
• InChI: 1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)
• chave InChI: PWKSKIMOESPYIA-UHFFFAOYSA-N

Descrição

Descrição geral

A mucolytic agent and thio-based antioxidant. Increases the cellular pool of free-radical scavengers. Inhibits HIV replication. Prevents apoptotic death of neuronal cells. Antidote for acetaminophen poisoning. May serve as a substrate for microsomal glutathione transferase. Induces apoptosis in human and rat smooth muscle cells.

Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock. Increases cellular pools of free-radical scavengers. Inhibitor of HIV replication. May serve as a substrate for microsomal glutathione transferase. Induces apoptosis in human and rat smooth muscle cells.

Aplicação

• Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages.: The study highlights the protective role of N-acetyl-L-cysteine against chlorpyrifos-induced oxidative damage in macrophages, emphasizing its importance in mitigating pesticide toxicity (Lu et al., 2024).


• N-Acetyl-L-Cysteine Attenuates Titanium Dioxide Nanoparticle (TiO2 NP)-Induced Autophagy in Male Germ Cells.: This research explores how N-acetyl-L-cysteine can mitigate the autophagic effects induced by titanium dioxide nanoparticles in male germ cells, suggesting its use in reproductive health (Shin et al., 2024).

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.

Outras notas

Ortolani, O., et al. 2000. Am. J. Respir. Crit. Care Med. 161, 1907.
Tsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
Ferrari, G., et al. 1995. J. Neurosci.15, 2857.
Weinander, R., et al. 1994. J. Biol. Chem.269, 71.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H319
• Declarações de precaução: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classificações de perigo: Eye Irrit. 2
• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable