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Merck
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Documentos Principais

06-900

Sigma-Aldrich

Anti-SynGAP Antibody

Upstate®, from rabbit

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

purified antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

rat

fabricante/nome comercial

Upstate®

técnica(s)

immunocytochemistry: suitable
western blot: suitable

nº de adesão NCBI

NM_006772.1

nº de adesão UniProt

Q9QUH6

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... SYNGAP1(8831)

Descrição geral

Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.

Especificidade

SynGAP

Imunogênio

peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1289-1308 of rat SynGAP-a

Aplicação

Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).
Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology

Ligação

Replaces: 04-1071

forma física

Format: Purified
Protein A purified
Purified in PBS with 0.05% NaN3 and 30% Glycerol

Armazenamento e estabilidade

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Characterization of a novel synGAP isoform, synGAP-beta.
Li, W; Okano, A; Tian, QB; Nakayama, K; Furihata, T; Nawa, H; Suzuki, T
The Journal of Biological Chemistry null
Ayse Dosemeci et al.
FEBS letters, 590(17), 2934-2939 (2016-08-02)
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B, also known as AIDA-1) is a major component of the postsynaptic density (PSD) in excitatory neurons where it concentrates at the electron-dense core under basal conditions and moves out during
SynGAP isoforms exert opposing effects on synaptic strength.
McMahon, AC; Barnett, MW; O'Leary, TS; Stoney, PN; Collins, MO; Papadia, S; Choudhary et al.
Nature Communications null
MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus.
Qiu, S; Lu, Z; Levitt, P
The Journal of Neuroscience null
Yuko Tanabe et al.
Nature communications, 8(1), 408-408 (2017-09-03)
Coordinated development of excitatory and inhibitory synapses is essential for higher brain function, and impairment in this development is associated with neuropsychiatric disorders. In contrast to the large body of accumulated evidence regarding excitatory synapse development, little is known about

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