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Merck
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Key Documents

06-501

Sigma-Aldrich

Anti-STAT1 Antibody, CT

Upstate®, from rabbit

Sinônimo(s):

Anti-CANDF7, Anti-IMD31A, Anti-IMD31B, Anti-IMD31C, Anti-ISGF-3, Anti-STAT91

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

purified antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

mouse, human

fabricante/nome comercial

Upstate®

técnica(s)

electrophoretic mobility shift assay: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG

nº de adesão NCBI

NM_007315

nº de adesão UniProt

P42224

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... STAT1(6772)

Descrição geral

STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway.

STAT 1, is activated by a number of different ligands, including IFNalpha, IFNgamma, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions.

Especificidade

Recognizes STAT1.

Imunogênio

GST fusion-protein containing the carboxy terminal 36 amino acids of human STAT1α

Aplicação

Detect STAT1 also known as Signal Transducer & Activator of Transcription 1 with Anti-STAT1 Antibody, CT (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA, IP & WB.

Qualidade

routinely evaluated by immunoblot on RIPA lysates from human Jurkat cells, mouse CTLL or rat L6 cells

Descrição-alvo

91 kDa

forma física

Format: Purified

Nota de análise

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Descrição
Preços

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation.
Rodriguez, JJ; Parisien, JP; Horvath, CM
Journal of virology null
Thrombopoietin signal transduction in purified murine megakaryocytes.
Drachman, J G, et al.
Blood, 89, 483-492 (1997)
Inhibition of interferon regulatory factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3
Sato, T., et al
Blood, 90, 4749-4758 (1997)
Ahmed A Mostafa et al.
PloS one, 9(1), e87377-e87377 (2014-01-30)
The coordinate regulation of HLA class II (HLA-II) is controlled by the class II transactivator, CIITA, and is crucial for the development of anti-tumor immunity. HLA-II in breast carcinoma is associated with increased IFN-γ levels, reduced expression of the estrogen
IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells.
Sriram, U; Xu, J; Chain, RW; Varghese, L; Chakhtoura, M; Bennett, HL; Zoltick, PW; Gallucci, S
Testing null
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