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05-822

Sigma-Aldrich

Anti-Rho (-A, -B, -C) Antibody, clone 3L74, rabbit monoclonal

clone 3L74, Upstate®, from rabbit

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

purified antibody

tipo de produto de anticorpo

primary antibodies

clone

3L74, monoclonal

reatividade de espécies

rat, human

fabricante/nome comercial

Upstate®

técnica(s)

western blot: suitable

Isotipo

IgG

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... RHOA(387)

Especificidade

Broad species cross-reactivity expected based on sequence homology
Recognizes Rho (-A, -B, -C)

Imunogênio

KLH-conjugated, synthetic peptide (SYPDTDVILMCFSIDSPDSLENKK) corresponding to amino acids 73-94 of human Rho (-A, -B, -C), with two terminal lysines added to increase peptide solubility

Aplicação

Anti-Rho (-A Antibody, -B, -C), clone 3L74 is an antibody against Rho (-A, -B, -C) for use in WB.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Qualidade

routinely evaluated by immunoblot on modified RIPA lysates from HL-60 cells

Descrição-alvo

Mr 22kDa

forma física

Format: Purified
Protein A purified

Armazenamento e estabilidade

Stable for 2 years at -20°C from date of shipment

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1


Certificados de análise (COA)

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Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers.
Jiang, Wen G, et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 9, 6432-6440 (2003)
D T Denhardt
The Biochemical journal, 318 ( Pt 3), 729-747 (1996-09-15)
The features of three distinct protein phosphorylation cascades in mammalian cells are becoming clear. These signalling pathways link receptor-mediated events at the cell surface or intracellular perturbations such as DNA damage to changes in cytoskeletal structure, vesicle transport and altered
Kyucheol Cho et al.
Journal of cell science, 123(Pt 23), 4128-4144 (2010-11-11)
In common with other p120-catenin subfamily members, Xenopus ARVCF (xARVCF) binds cadherin cytoplasmic domains to enhance cadherin metabolic stability or, when dissociated, modulates Rho-family GTPases. We report here that xARVCF binds and is stabilized by Xenopus KazrinA (xKazrinA), a widely
S Vincent et al.
Molecular and cellular biology, 17(4), 2247-2256 (1997-04-01)
The Ras-related Rho family GTPases mediate signal transduction pathways that regulate a variety of cellular processes. Like Ras, the Rho proteins (which include Rho, Rac, and CDC42) interact directly with protein kinases, which are likely to serve as downstream effector
Stanislav Kholmanskikh et al.
Scientific reports, 12(1), 16493-16493 (2022-10-04)
Regulation of Rho GTPases remains a topic of active investigation as they are essential participants in cell biology and the pathophysiology of many human diseases. Non-degrading ubiquitination (NDU) is a critical regulator of the Ras superfamily, but its relevance to

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