05-636-AF647
Anti-phospho Histone H2A.X (Ser139) Antibody, clone JBW301, Alexa Fluor™ 647
clone JBW301, 0.5 mg/mL, from mouse
Sinônimo(s):
Histone H2AX, H2a/x, Histone H2A.X
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
ALEXA FLUOR™ 647
forma do anticorpo
purified antibody
tipo de produto de anticorpo
primary antibodies
clone
JBW301, monoclonal
reatividade de espécies
human
reatividade da espécie (prevista por homologia)
vertebrates (based on 100% sequence homology)
concentração
0.5 mg/mL
técnica(s)
immunocytochemistry: suitable
Isotipo
IgG1
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
phosphorylation (pSer139)
Informações sobre genes
human ... H2AX(3014)
Descrição geral
As a member of the histone H2A family, histone H2A.x (H2A.x) is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. H2A.x is involved in the DNA repair of double-strand breakage (DSB) damage on nuclear DNA. After a double strand DNA break, H2A.x is rapidly phosphorylated at serine 139 by ATM kinase and becomes gamma-H2AFX. This phosphorylation step can extend up to several thousand nucleosomes from the actual site of the DSB and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. As a part of posttranslational modifications during apoptosis caused by severe DNA damage, high expression of phosphorylated H2A.x is considered as an accurate indicator of apoptosis.
Imunogênio
Linear peptide corresponding to phospho Histone H2A.X (Ser139).
Aplicação
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
This Anti-phospho Histone H2A.X (Ser139) Antibody, clone JBW301, Alexa Fluor™ 647 is validated for use in ICC for the detection of phospho Histone H2A.X (Ser139).
Qualidade
Evaluated by Immunocytochemistry in untreated and staurosporin treated HeLa cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H2A.X (Ser139) in staurosporin treated HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H2A.X (Ser139) in staurosporin treated HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Descrição-alvo
~17 kDa observed. Refer to Cat. No. 05-636 for observed molecular weight information.
forma física
Protein G Purified
Purified mouse conjugate in buffer containing PBS, 15 mg/ml BSA and 0.1% sodium azide.
Armazenamento e estabilidade
Stable for 1 year at 2-8°C from date of receipt.
Informações legais
ALEXA FLUOR is a trademark of Life Technologies
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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