E-070

Everolimus-D₄ solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (Notação de Hill): C₅₃H₇₉NO₁₄D₄
• Número CAS: 1338452-54-2
• Peso molecular: 962.25
• Número CE: 200-835-2
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: certified reference material
• forma: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• embalagem: ampule of 1 mL
• fabricante/nome comercial: Cerilliant^®
• concentração: 100 μg/mL in acetonitrile
• técnica(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicação(ões): clinical testing
• formato: single component solution
• temperatura de armazenamento: −70°C
• cadeia de caracteres SMILES: [2H]C([2H])(O)C([2H])([2H])OC1CCC(CC(C)C2CC(=O)C(C)\C=C(C)\C(O)C(OC)C(=O)C(C)CC(C)\C=C\C=C\C=C(C)\C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC)CC1OC
• InChI: 1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/i24D2,25D2
• chave InChI: HKVAMNSJSFKALM-ULVVDLMCSA-N

Descrição

Descrição geral

A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress^® and Certican for use in organ transplantation and Afinitor^® for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

Aplicação

• Quantitative Bioanalysis in Therapeutic Drug Monitoring: Everolimus-D₄ is utilized as an internal standard in LC-MS/MS methods for the quantification of everolimus, highlighting its application in the pharmacokinetic studies of mTOR inhibitors. This method ensures accuracy and precision in therapeutic drug monitoring, crucial for optimizing dosages in cancer treatments and immunosuppressive therapies (Heideloff et al., 2013).


• Multi-Drug Analysis in Transplantation Medicine: The use of Everolimus-D₄ as a deuterated internal standard supports ultra-fast liquid chromatography-tandem mass spectrometry methods for simultaneously measuring multiple immunosuppressants in whole blood. This technique is vital for managing drug interactions and therapeutic levels in patients undergoing organ transplantation, which involves targeted therapy and mTOR inhibitors (Meinitzer et al., 2010).

Informações legais

Afinitor is a registered trademark of Novartis AG

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Zortress is a registered trademark of Novartis AG

Informações de segurança

• Pictogramas: GHS02,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H302 + H312 + H332,H319
• Declarações de precaução: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 35.6 °F - closed cup
• Ponto de fulgor (°C): 2 °C - closed cup