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B1378

Sigma-Aldrich

2,6-Di-tert-butyl-4-methylphenol

≥99.0% (GC), powder

Sinônimo(s):

2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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About This Item

Fórmula linear:
[(CH3)3C]2C6H2(CH3)OH
Número CAS:
128-37-0
Peso molecular:
220.35
Beilstein:
1911640
Número CE:
204-881-4
Número MDL:
MFCD00011644
Código UNSPSC:
12352100
ID de substância PubChem:
57653920
NACRES:
NA.22

densidade de vapor

7.6 (vs air)

pressão de vapor

<0.01 mmHg ( 20 °C)

Ensaio

≥99.0% (GC)

Formulário

powder

temperatura de autoignição

878 °F

p.e.

265 °C (lit.)

pf

69-73 °C (lit.)

solubilidade

ethanol: 100 mg/mL
vegetable oils: soluble

cadeia de caracteres SMILES

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

chave InChI

NLZUEZXRPGMBCV-UHFFFAOYSA-N

Informações sobre genes

human ... CAPN1(823)
rat ... Capn1(29153) , Nos1(24598)

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Aplicação

  • Thermal decomposition characteristics of BHT and its peroxide (BHTOOH): BHT is highlighted for its excellent antioxidant properties, which degrade into BHTOOH under specific conditions (S Dai, et al., 2024).
  • Relaxation mechanisms in low-stress polymer networks: BHT is utilized in polymer networks to assess its effects on the mechanical properties and durability of dental composites (SH Lewis, et al., 2024).
  • Compatibility and safety of labels for pharmaceutical packaging: The study found BHT in labels, indicating its widespread use in pharmaceutical packaging due to its stabilizing properties (C Fu, et al., 2023).

Ações bioquímicas/fisiológicas

Butylated hydroxytoluene (BHT) is a phenolic antioxidant. It has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.

produto relacionado

Nº do produto
Descrição
Preços

912395

NaBHT

Pictogramas

Environment
GHS09

Palavra indicadora

Warning

Frases de perigo

H410

Declarações de precaução

P273 - P391 - P501

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

260.6 °F - open cup

Ponto de fulgor (°C)

127 °C - open cup

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
SHBL6695
0000123733
0000123732
0000117922
0000117923

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Sigma-Aldrich

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Sigma-Aldrich

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2-tert-Butyl-4-methylphenol

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Sigma-Aldrich

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