936480

2,7-Diazaspiro[3.5]nonane-7-acetic acid, 2-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-

≥95%

• Sinônimo(s): 2-(2-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,7-diazaspiro[3.5]nonan-7-yl)acetic acid, 2-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2,7-diazaspiro[3.5]nonane-7-acetic acid
• Fórmula empírica (Notação de Hill): C₂₂H₂₄N₄O₆
• Número CAS: 2566692-78-0
• Peso molecular: 440.45
• Código UNSPSC: 12352106
• NACRES: NA.22

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95%
• Formulário: powder or crystals
• cor: Light Yellow to Yellow
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(O)CN1CCC2(CN(C3=CC=C4C(=O)N(C(=O)C4=C3)C5C(=O)NC(=O)CC5)C2)CC1
• chave InChI: VCIGJJAMFQFWKB-UHFFFAOYSA-N

Descrição

Aplicação

This is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Outras notas

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable